Expression Profiling of Transcriptome and Its Associated Disease Risk in Yang Deficiency Constitution of Healthy Subjects
Joint Authors
Yu, Ruoxi
Yang, Yin
Han, Yuanyuan
Hou, Pengwei
Li, Yingshuai
Li, Siqi
Wang, Qi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Differences among healthy subjects and associated disease risks are of substantial interest in clinical medicine.
According to the theory of “constitution-disease correlation” in traditional Chinese medicine, we try to find out if there is any connection between intolerance of cold in Yang deficiency constitution and molecular evidence and if there is any gene expression basis in specific disorders.
Methods.
Peripheral blood mononuclear cells were collected from Chinese Han individuals with Yang deficiency constitution (n=20) and balanced constitution (n=8) (aged 18–28) and global gene expression profiles were determined between them using the Affymetrix HG-U133 Plus 2.0 array.
Results.
The results showed that when the fold change was ≥1.2 and q ≤ 0.05, 909 genes were upregulated in the Yang deficiency constitution, while 1189 genes were downregulated.
According to our research differential genes found in Yang deficiency constitution were usually related to lower immunity, metabolic disorders, and cancer tendency.
Conclusion.
Gene expression disturbance exists in Yang deficiency constitution, which corresponds to the concept of constitution and gene classification.
It also suggests people with Yang deficiency constitution are susceptible to autoimmune diseases, enteritis, arthritis, metabolism disorders, and cancer, which provides molecular evidence for the theory of “constitution-disease correlation.”
American Psychological Association (APA)
Yu, Ruoxi& Yang, Yin& Han, Yuanyuan& Hou, Pengwei& Li, Yingshuai& Li, Siqi…[et al.]. 2016. Expression Profiling of Transcriptome and Its Associated Disease Risk in Yang Deficiency Constitution of Healthy Subjects. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103906
Modern Language Association (MLA)
Yu, Ruoxi…[et al.]. Expression Profiling of Transcriptome and Its Associated Disease Risk in Yang Deficiency Constitution of Healthy Subjects. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103906
American Medical Association (AMA)
Yu, Ruoxi& Yang, Yin& Han, Yuanyuan& Hou, Pengwei& Li, Yingshuai& Li, Siqi…[et al.]. Expression Profiling of Transcriptome and Its Associated Disease Risk in Yang Deficiency Constitution of Healthy Subjects. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103906