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Liuwei Dihuang Pills Enhance the Effect of Western Medicine in Treating Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Lin, Lan
Wang, Qiuhong
Yi, Yongxin
Wang, Shihan
Qiu, Zonglin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To assess the effectiveness and adverse effects of adding Liuwei Dihuang Pills (LDP) to Western medicine for treating diabetic nephropathy.
Methods.
Studies were retrieved from seven electronic databases, including PubMed, Embase, The Cochrane Library, CBM, CNKI, Chinese Scientific Journal Database (VIP), and Wanfang Data until November 2015.
Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards.
Meta-analysis was performed on the overall therapeutic efficacy of hyperglycemia and renal functions, and the study also analyzed adverse events.
Results.
A total of 1,275 patients from 18 studies were included.
The methodological quality of these included trials was generally low.
We found that adding LDP can lower patients’ FBG (MD: −0.36 [−0.46, −0.25], P<0.00001), PBG (MD: −1.10 [−1.35, −0.85], P<0.00001), and HbA1c (MD: −0.14 [−0.49, 0.21], P=0.43).
There were also improvements in lowering patients’ BUN (MD: −0.67 [−0.89, −0.45], P<0.00001), SCr (MD: −0.96 [−1.53, −0.39], P<0.00001), 24 h UTP (SMD: −1.26 [−2.38, −0.15], P<0.00001), UAER (MD: −26.18 [−27.51, −24.85], P<0.00001), and UmAlb (SMD: −1.72 [−2.67, −0.77], P<0.00001).
Conclusion.
There is encouraging evidence that adding LDP to Western medicine might improve treatment outcomes of diabetic nephropathy, including hyperglycemia and renal functions.
However, the evidence remains weak.
More rigorous high-quality trials are warranted to substantiate or refute the results.
American Psychological Association (APA)
Lin, Lan& Wang, Qiuhong& Yi, Yongxin& Wang, Shihan& Qiu, Zonglin. 2016. Liuwei Dihuang Pills Enhance the Effect of Western Medicine in Treating Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103909
Modern Language Association (MLA)
Lin, Lan…[et al.]. Liuwei Dihuang Pills Enhance the Effect of Western Medicine in Treating Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103909
American Medical Association (AMA)
Lin, Lan& Wang, Qiuhong& Yi, Yongxin& Wang, Shihan& Qiu, Zonglin. Liuwei Dihuang Pills Enhance the Effect of Western Medicine in Treating Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103909