Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke

Abstract EN

Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress.

However, the mechanism is still unknown.

In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks.

Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning.

A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.