Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats
Joint Authors
Liu, Lu
Pei, Pei
Zhao, Luo-Peng
Qu, Zheng-Yang
Zhu, Yu-Pu
Wang, Lin-Peng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
While electroacupuncture (EA) pretreatment in migraine has been found to attenuate pain and frequencies of attacks, the underlying mechanism of its antinociceptive effect remains poorly understood.
Emerging evidence suggests that the serotonin system may be involved in migraine pathophysiology.
Method.
Forty male Sprague-Dawley rats were randomly assigned to Control, Model, EA, and sham acupuncture (SA) groups.
HomeCageScan was used to measure the effects on spontaneous nociceptive behaviors.
Radioimmunoassay and high-performance liquid chromatography were used to evaluate the expression of 5-hydroxytryptamine (HT) in the plasma and three-key structure of the descending pain modulatory system.
Results.
Our study showed that EA pretreatment could produce a significant reduction in resting, freezing, and grooming behavior and a significant increase in exploration behavior.
Furthermore, we found that the level of 5-HT in plasma was significantly increased, and it was significantly decreased in the descending pain modulatory system in Model group.
The aforementioned results were significantly reversed in EA group; that is, the level of 5-HT was increased in the rostroventromedial medulla (RVM) and trigeminal nucleus caudalis (TNC) region and decreased in the plasma.
Conclusion.
EA pretreatment exerts antinociceptive effects in a rat model of recurrent migraine, possibly via modulation of the serotonin system.
American Psychological Association (APA)
Liu, Lu& Pei, Pei& Zhao, Luo-Peng& Qu, Zheng-Yang& Zhu, Yu-Pu& Wang, Lin-Peng. 2016. Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103933
Modern Language Association (MLA)
Liu, Lu…[et al.]. Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103933
American Medical Association (AMA)
Liu, Lu& Pei, Pei& Zhao, Luo-Peng& Qu, Zheng-Yang& Zhu, Yu-Pu& Wang, Lin-Peng. Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103933