The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract
Joint Authors
Heo, Yunwi
Bae, Seong Kyeong
Lee, Hyunkyoung
Kang, Changkeun
Kim, Euikyung
Kim, Na-Hyun
Yang, Hyeryeon
Choudhary, Indu
Kwon, Young Chul
Byun, Jae Kuk
Yim, Hyeong Jun
Noh, Byung Seung
Heo, Jeong-Doo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rumex japonicus Houtt.
is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea.
However, the beneficial effect of Rumex japonicus Houtt.
on hair growth has not been thoroughly examined.
Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt.
root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model.
RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt.
RJ also increased β-catenin via the inhibition of GSK-3β.
In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period.
Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and β-catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation.
These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth.
American Psychological Association (APA)
Lee, Hyunkyoung& Kim, Na-Hyun& Yang, Hyeryeon& Bae, Seong Kyeong& Heo, Yunwi& Choudhary, Indu…[et al.]. 2016. The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103936
Modern Language Association (MLA)
Lee, Hyunkyoung…[et al.]. The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103936
American Medical Association (AMA)
Lee, Hyunkyoung& Kim, Na-Hyun& Yang, Hyeryeon& Bae, Seong Kyeong& Heo, Yunwi& Choudhary, Indu…[et al.]. The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103936