Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer’s Disease
Joint Authors
Hsu, Chih-Hsiang
Wang, Sheue-Er
Lin, Ching-Lung
Hsiao, Chun-Jen
Sheu, Shuenn-Jyi
Wu, Chung-Hsin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
In this study, we have reported the herbal formula B401 that has neuroprotective effects via multifunction, multitarget characteristics.
It is possible that the herbal formula B401 may also provide new insights for AD.
Here, we studied protective effects in the Tet-On Aβ42-GFP SH-SY5Y cell model and the APP/PS1/Tau triple transgenic mouse model by the herbal formula B401.
In in vitro experiments, we showed that the herbal formula B401 treatment effectively reduces glutamate-induced excitotoxicity and acetylcholinesterase activity in Tet-On Aβ42-GFP SH-SY5Y cells.
In in vivo experiments, we found that oral B401 treatment effectively ameliorates neurocognitive dysfunctions of 3× Tg-AD mice via motor and cognitive behavior tests.
By using magnetic resonance imaging, moorFLPI instruments, and chemiluminescence methods, we reported that oral B401 treatment effectively alleviates brain atrophy, improves subcutaneous blood flow, and reduces blood ROS in 3× Tg-AD mice.
As observed from results of immunohistochemistry staining and western blotting, we found that oral B401 treatment significantly enhances expressions of neuroprotective proteins, while reducing expressions of AD derived proteins such as amyloid beta, phosphorylated Tau, neurofibrillary tangles, and 3-nitrotyrosine in the brain of 3× Tg-AD mice.
Thus, the herbal formula B401 may have the potential to be developed into optimum TCM for AD patients.
American Psychological Association (APA)
Hsu, Chih-Hsiang& Wang, Sheue-Er& Lin, Ching-Lung& Hsiao, Chun-Jen& Sheu, Shuenn-Jyi& Wu, Chung-Hsin. 2016. Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1103944
Modern Language Association (MLA)
Hsu, Chih-Hsiang…[et al.]. Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1103944
American Medical Association (AMA)
Hsu, Chih-Hsiang& Wang, Sheue-Er& Lin, Ching-Lung& Hsiao, Chun-Jen& Sheu, Shuenn-Jyi& Wu, Chung-Hsin. Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1103944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103944