Anti-Inflammatory and Antiosteoarthritis Effects of Saposhnikovia divaricata ethanol Extract: In Vitro and In Vivo Studies
Joint Authors
Kim, Seung-Hyung
Chun, Jin Mi
Kim, Hyo Seon
Lee, A Yeong
Kim, Ho Kyoung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Saposhnikovia divaricata Schischkin has been used in traditional medicine to treat pain, inflammation, and arthritis.
The aim of this study was to investigate the anti-inflammatory and antiosteoarthritis activities of Saposhnikovia divaricata extract (SDE).
The anti-inflammatory effect of SDE was evaluated in vitro in lipopolysaccharide- (LPS-) treated RAW 264.7 cells.
The antiosteoarthritic effect of SDE was investigated in an in vivo rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis (OA) in which rats were treated orally with SDE (200 mg/kg) for 28 days.
The effects of SDE were assessed in vivo by histopathological analysis and by measuring weight-bearing distribution, cytokine serum levels, and joint tissue inflammation-related gene expression.
SDE showed anti-inflammatory activity by inhibiting the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in LPS-induced RAW 264.7 cells.
In addition, SDE promoted recovery of hind limb weight-bearing, inhibited the production of proinflammatory cytokines and mediators, and protected cartilage and subchondral bone tissue in the OA rat model.
Therefore, SDE is a potential therapeutic agent for OA and/or associated symptoms.
American Psychological Association (APA)
Chun, Jin Mi& Kim, Hyo Seon& Lee, A Yeong& Kim, Seung-Hyung& Kim, Ho Kyoung. 2016. Anti-Inflammatory and Antiosteoarthritis Effects of Saposhnikovia divaricata ethanol Extract: In Vitro and In Vivo Studies. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103949
Modern Language Association (MLA)
Chun, Jin Mi…[et al.]. Anti-Inflammatory and Antiosteoarthritis Effects of Saposhnikovia divaricata ethanol Extract: In Vitro and In Vivo Studies. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103949
American Medical Association (AMA)
Chun, Jin Mi& Kim, Hyo Seon& Lee, A Yeong& Kim, Seung-Hyung& Kim, Ho Kyoung. Anti-Inflammatory and Antiosteoarthritis Effects of Saposhnikovia divaricata ethanol Extract: In Vitro and In Vivo Studies. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103949