The Effects of Chunghyul-Dan (A Korean Medicine Herbal Complex) on Cardiovascular and Cerebrovascular Diseases: A Narrative Review
Joint Authors
Moon, Sang Kwan
Park, Jung-Mi
Ko, Chang-Nam
Cho, Seung-Yeon
Kwon, SeungWon
Jung, Woo Sang
Park, Seong-Uk
Cho, KiHo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chunghyul-dan (CHD) is a herbal complex containing 80% ethanol extract and is composed of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, Gardeniae Fructus, and Rhei Rhizoma.
We have published several experimental and clinical research articles on CHD.
It has shown antilipidemic, antihypertensive, antiatherosclerotic, and inhibitory effects on ischemic stroke recurrence with clinical safety in the previous studies.
The antilipidemic effect of CHD results from 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and pancreatic lipase-inhibitory activity.
The antihypertensive effect likely results from the inhibitory effect on endogenous catecholamine(s) release and harmonization of all components showing the antihypertensive effects.
Furthermore, anti-inflammatory and antioxidant effects on endothelial cells are implicated to dictate the antiatherosclerotic effects of CHD.
It also showed neuroprotective effects on cerebrovascular and parkinsonian models.
These effects of CHD could be helpful for the prevention of the recurrence of ischemic stroke.
Therefore, we suggest that CHD could be a promising medication for treating and preventing cerebrovascular and cardiovascular diseases.
However, to validate and better understand these findings, well-designed clinical studies are required.
American Psychological Association (APA)
Jung, Woo Sang& Kwon, SeungWon& Cho, Seung-Yeon& Park, Seong-Uk& Moon, Sang Kwan& Park, Jung-Mi…[et al.]. 2016. The Effects of Chunghyul-Dan (A Korean Medicine Herbal Complex) on Cardiovascular and Cerebrovascular Diseases: A Narrative Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103999
Modern Language Association (MLA)
Jung, Woo Sang…[et al.]. The Effects of Chunghyul-Dan (A Korean Medicine Herbal Complex) on Cardiovascular and Cerebrovascular Diseases: A Narrative Review. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103999
American Medical Association (AMA)
Jung, Woo Sang& Kwon, SeungWon& Cho, Seung-Yeon& Park, Seong-Uk& Moon, Sang Kwan& Park, Jung-Mi…[et al.]. The Effects of Chunghyul-Dan (A Korean Medicine Herbal Complex) on Cardiovascular and Cerebrovascular Diseases: A Narrative Review. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103999