Soshiho-Tang Aqueous Extract Exerts Antiobesity Effects in High Fat Diet-Fed Mice and Inhibits Adipogenesis in 3T3-L1 Adipocytes
Joint Authors
Shin, Hyeun-Kyoo
Kang, Byoung-Kab
Yoo, Sae-Rom
Jeong, Soo-Jin
Lee, Mee-Young
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Soshiho-tang (SST; sho-saiko-to in Japanese; xiaochaihu-tang in Chinese) has generally been used to improve liver fibrosis- and cirrhosis-related symptoms in traditional Korean medicine.
Although many studies have investigated the pharmacological properties of SST, its antiobesity effect has not been elucidated.
Thus, our present study was carried out to evaluate the antiobesity effect of SST using a high fat diet- (HFD) induced obese mouse model and 3T3-L1 adipose cells.
C57BL/6J mice were randomly divided into four groups ( n = 6 /group), normal diet (ND), HFD-fed group, and HFD- and SST-fed groups (S200: 200 mg/kg of SST; S600: 600 mg/kg of SST) and given HFD with or without SST extract for 8 weeks.
3T3-L1 preadipocytes were differentiated into adipocytes for 8 days with or without SST.
In the HFD-fed obese mice, body weight and fat accumulation in adipose tissue were significantly reduced by SST administration.
Compared with control-differentiated adipocytes, SST significantly inhibited lipid accumulation by decreasing the triglyceride (TG) content and leptin concentration in 3T3-L1 adipocytes.
SST also decreased the expression of adipogenesis-related genes including lipoprotein lipase (LPL), fatty acid binding protein 4 (FABP4), CCAAT/enhancer-binding protein-alpha (C/EBP-α), and peroxisome proliferator-activated receptor-gamma (PPAR-γ).
Our findings suggest that SST has potential as a nontoxic antiobesity medication.
American Psychological Association (APA)
Yoo, Sae-Rom& Lee, Mee-Young& Kang, Byoung-Kab& Shin, Hyeun-Kyoo& Jeong, Soo-Jin. 2016. Soshiho-Tang Aqueous Extract Exerts Antiobesity Effects in High Fat Diet-Fed Mice and Inhibits Adipogenesis in 3T3-L1 Adipocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104005
Modern Language Association (MLA)
Yoo, Sae-Rom…[et al.]. Soshiho-Tang Aqueous Extract Exerts Antiobesity Effects in High Fat Diet-Fed Mice and Inhibits Adipogenesis in 3T3-L1 Adipocytes. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104005
American Medical Association (AMA)
Yoo, Sae-Rom& Lee, Mee-Young& Kang, Byoung-Kab& Shin, Hyeun-Kyoo& Jeong, Soo-Jin. Soshiho-Tang Aqueous Extract Exerts Antiobesity Effects in High Fat Diet-Fed Mice and Inhibits Adipogenesis in 3T3-L1 Adipocytes. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104005