The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease
Joint Authors
Xi, Shengyan
Yue, Lifeng
Shi, Mengmeng
Peng, Ying
Xu, Yangxinzi
Wang, Xinrong
Li, Qian
Kang, Zhijun
Li, Hanjing
Wang, Yanhui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chronic liver disease is one of the most common diseases that threaten human health.
Effective treatment is still lacking in western medicine.
Semen Persicae (Taoren) and Flos Carthami (Honghua) are known to relieve acute hepatic injury and inflammation, improve microcirculation, and reduce tissue fiber.
The aim of our study is to investigate the potential mechanisms of Taoren-Honghua Herb Pair (THHP) in murine model of chronic liver disease caused by Carbon Tetrachloride (CCl4).
Mice were randomly divided into seven groups: (1) blank, (2) model, (3) control (colchicine, 0.1 mg/kg), (4) THHP (5.53, 2.67, and 1.33 g/kg), and (5) Tao Hong Siwu Decoction (THSWD) (8.50 g/kg).
Histological change and microvessels density were examined by microscopy.
Hepatic function, serum fibrosis related factors, and hepatic vascular endothelial growth factor (VEGF) were measured with ELISA.
VEGF, kinase insert domain-containing receptor (KDR), Flt-1, and Akt mRNA expression in hepatic tissue were determined with PCR.
Tissues of Akt, pAkt, KDR, and Flt-1 were measured with western blotting.
Data from this study showed that THHP improved hepatic function and restrained the hepatic inflammation and fibrosis.
Its role in inhibiting pathological angiogenesis and hepatic fibrogenesis may be through affecting the angiogenesis-associated VEGF and its upstream and downstream signaling pathways.
American Psychological Association (APA)
Xi, Shengyan& Yue, Lifeng& Shi, Mengmeng& Peng, Ying& Xu, Yangxinzi& Wang, Xinrong…[et al.]. 2016. The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104033
Modern Language Association (MLA)
Xi, Shengyan…[et al.]. The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104033
American Medical Association (AMA)
Xi, Shengyan& Yue, Lifeng& Shi, Mengmeng& Peng, Ying& Xu, Yangxinzi& Wang, Xinrong…[et al.]. The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104033