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Efficacy of Compound Kushen Injection in Combination with Induction Chemotherapy for Treating Adult Patients Newly Diagnosed with Acute Leukemia
Joint Authors
Zhou, Fuling
Tu, Honglei
Lei, Bo
Meng, Shan
Liu, Hailing
Wei, Yongchang
He, Aili
Zhang, Wanggang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We assessed the clinical effectiveness and safety of CKI (compound Kushen injection) plus standard induction chemotherapy for treating adult acute leukemia (AL).
We randomly assigned 332 patients with newly diagnosed AL to control (n = 165, receiving DA (daunorubicin and cytarabine) or hyper-CVAD (fractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone)) or treatment (n = 167, receiving CKI and DA or hyper-CVAD) groups.
Posttreatment, treatment group CD3+, CD4+, CD4+/CD8+, natural killer (NK) cell, and immunoglobulin (IgG, IgA, and IgM) levels were significantly higher than those of the control group ( p < 0.05), and CD8+ levels were lower in the treatment group than in the control group ( p < 0.05).
Treatment group interleukin- (IL-) 4 and IL-10 levels were significantly higher compared to the control posttreatment (both p < 0.05) as were complete remission, overall response, and quality of life (QoL) improvement rates (p < 0.05).
The control group had more incidences of grade 3/4 hematologic and nonhematologic toxicity (p < 0.05).
Responses to induction chemotherapy, QoL improvement, and adverse events incidence between control group patients with acute myeloid leukemia and acute lymphocytic leukemia were not significantly different.
CKI plus standard induction chemotherapy is effective and safe for treating AL, possibly by increasing immunologic function.
American Psychological Association (APA)
Tu, Honglei& Lei, Bo& Meng, Shan& Liu, Hailing& Wei, Yongchang& He, Aili…[et al.]. 2016. Efficacy of Compound Kushen Injection in Combination with Induction Chemotherapy for Treating Adult Patients Newly Diagnosed with Acute Leukemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104043
Modern Language Association (MLA)
Tu, Honglei…[et al.]. Efficacy of Compound Kushen Injection in Combination with Induction Chemotherapy for Treating Adult Patients Newly Diagnosed with Acute Leukemia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104043
American Medical Association (AMA)
Tu, Honglei& Lei, Bo& Meng, Shan& Liu, Hailing& Wei, Yongchang& He, Aili…[et al.]. Efficacy of Compound Kushen Injection in Combination with Induction Chemotherapy for Treating Adult Patients Newly Diagnosed with Acute Leukemia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104043