Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells
Joint Authors
Park, Jun Yeon
Lee, Dahae
Kang, Ki Sung
Choi, Pilju
Kim, Taejung
Jung, Eun Bee
Hwang, Buyng-Su
Ham, Jungyeob
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ginsenosides are the active components of Panax ginseng.
Many research studies indicate that these deglycosylated, less-polar ginsenosides have better bioactivity than the major ginsenosides.
In the present study, we sought to verify the enhanced anticancer effect of P.
ginseng extract after undergoing the Maillard reaction as well as elucidate the underlying mechanism of action.
The effects of 9 amino acids were tested; among them, the content of 20(S)-Rg3 in the ginseng extract increased to more than 30, 20, and 20% when processed with valine, arginine, and alanine, respectively, compared with that after normal heat processing.
The ginseng extract that was heat-processed with arginine exhibited the most potent inhibitory effect on A2780 ovarian cancer cell proliferation.
Therefore, the generation of 20(S)-Rg3 was suggested to be involved in this effect.
Moreover, the inhibitory effect of 20(S)-Rg3 on A2780 cell proliferation was significantly stronger than that of 20(R)-Rg3.
Protein expression levels of cleaved caspase-3, caspase-8, caspase-9, and PARP in the A2780 ovarian cancer cells markedly increased, whereas the expression of BID decreased after 20(S)-Rg3 treatment.
Therefore, we confirmed that the anticancer effects of the products of ginseng that was heat-processed with arginine are mediated mainly via the generation of the less-polar ginsenoside 20(S)-Rg3.
American Psychological Association (APA)
Park, Jun Yeon& Choi, Pilju& Lee, Dahae& Kim, Taejung& Jung, Eun Bee& Hwang, Buyng-Su…[et al.]. 2016. Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104046
Modern Language Association (MLA)
Park, Jun Yeon…[et al.]. Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104046
American Medical Association (AMA)
Park, Jun Yeon& Choi, Pilju& Lee, Dahae& Kim, Taejung& Jung, Eun Bee& Hwang, Buyng-Su…[et al.]. Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104046