Formula Compatibility Identification of Dachengqi Decoction Based on the Effects of Absorbed Components in Cerulein-Injured Pancreatic AR42J Cells
Joint Authors
Zhao, Xian-Lin
Tang, Wen-Fu
Zhao, Jianlei
Guo, Hui
Zhang, Yumei
Zhu, Lin
Wang, Jia
Li, Juan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To identify the herbal formula compatibility law based on the effects of the absorbed components from DCQD on the cerulein-injured AR42J cells.
Methods.
AR42J cells were pretreated for 30 min with or without the different concentrations of the absorbed components from DCQD individually or in combination or DCQD and coincubated with cerulein (10 nM) for a further 24 h.
Cell viability, lactate dehydrogenase (LDH) release, and the levels of apoptosis and necrosis were measured.
Results.
Compared to DCQD, the individual or combination components partially protected cerulein-injured AR42J cells by increasing cell viability, reducing LDH release, and promoting apoptosis.
Rhein, naringin, and honokiol were the main absorbed components from DCQD in cerulein-induced pancreatitis.
Moreover, rhein in combination with naringin and honokiol had synergistic effects in protecting cerulein-injured AR42J cells and was better than the individual or the pairwise combination of the three components.
Conclusions.
The ten effective components from DCQD may elicit similar protective effects as DCQD on cerulein-induced pancreatitis.
The principle of the formula compatibility of DCQD may be identified based on the effects of its absorbed components in cerulein-injured AR42J cells.
American Psychological Association (APA)
Zhang, Yumei& Zhu, Lin& Wang, Jia& Zhao, Jianlei& Zhao, Xian-Lin& Guo, Hui…[et al.]. 2016. Formula Compatibility Identification of Dachengqi Decoction Based on the Effects of Absorbed Components in Cerulein-Injured Pancreatic AR42J Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104055
Modern Language Association (MLA)
Zhang, Yumei…[et al.]. Formula Compatibility Identification of Dachengqi Decoction Based on the Effects of Absorbed Components in Cerulein-Injured Pancreatic AR42J Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104055
American Medical Association (AMA)
Zhang, Yumei& Zhu, Lin& Wang, Jia& Zhao, Jianlei& Zhao, Xian-Lin& Guo, Hui…[et al.]. Formula Compatibility Identification of Dachengqi Decoction Based on the Effects of Absorbed Components in Cerulein-Injured Pancreatic AR42J Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104055