A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis
Joint Authors
Zhang, Bai-xia
Tang, Huaqi
He, Shuaibing
Zhang, Xinyue
Luo, Shilin
Duan, Xiaojie
Zhang, Zhiqian
Wang, Wenqi
Wang, Yun
Sun, Yikun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As the most familiar type of arthritis and a chronic illness of the joints, Osteoarthritis (OA) affects a great number of people on the global scale.
XuanHuSuo powder (XHSP), a conventional herbal formula from China, has been extensively applied in OA treatment.
Nonetheless, its pharmacological mechanism has not been completely expounded.
In this research, a network pharmacology approach has been chosen to study the pharmacological mechanism of XHSP on OA, and the pharmacology networks were established based on the relationship between four herbs found in XHSP, compound targets, and OA targets.
The pathway enrichment analysis revealed that the significant bioprocess networks of XHSP on OA were regulation of inflammation, interleukin-1β (IL-1β) production and nitric oxide (NO) biosynthetic process, response to cytokine or estrogen stimuli, and antiapoptosis.
These effects have not been reported previously.
The comprehensive network pharmacology approach developed by our research has revealed, for the first time, a connection between four herbs found in XHSP, corresponding compound targets, and OA pathway systems that are conducive to expanding the clinical application of XHSP.
The proposed network pharmacology approach could be a promising complementary method by which researchers might better evaluate multitarget or multicomponent drugs on a systematic level.
American Psychological Association (APA)
Tang, Huaqi& He, Shuaibing& Zhang, Xinyue& Luo, Shilin& Zhang, Bai-xia& Duan, Xiaojie…[et al.]. 2016. A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104058
Modern Language Association (MLA)
Tang, Huaqi…[et al.]. A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104058
American Medical Association (AMA)
Tang, Huaqi& He, Shuaibing& Zhang, Xinyue& Luo, Shilin& Zhang, Bai-xia& Duan, Xiaojie…[et al.]. A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104058