Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy
Joint Authors
Hwang, Gwi Seo
Lee, Jinsoo
Son, Kwanghyun
Kim, Moonju
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Herbal medicine has been widely used to treat drug resistant epilepsy.
Shihogyejitang (SGT) has been commonly used to treat epilepsy.
We investigated the effect and safety of SGT in children with drug resistant epilepsy.
Design.
We reviewed medical records of 54 patients with epilepsy, who failed to respond to at least two antiepileptic drugs and have been treated with SGT between April 2006 and June 2014 at the Department of Pediatric Neurology, I-Tomato Hospital, Korea.
Effect was measured by the response rate, seizure-free rate, and retention rate at six months.
We also checked adverse events, change in antiepileptic drugs use, and the variables related to the outcome.
Results.
Intent-to-treat analysis showed that, after six months, 44.4% showed a >50% seizure reduction, 24.1% including seizure-free, respectively, and 53.7% remained on SGT.
Two adverse events were reported, mild skin rash and fever.
Focal seizure type presented significantly more positive responses when compared with other seizure types at six months (p=0.0284, Fisher’s exact test).
Conclusion.
SGT is an effective treatment with excellent tolerability for drug resistant epilepsy patients.
Our data provide evidence that SGT may be used as alternative treatment option when antiepileptic drug does not work in epilepsy children.
American Psychological Association (APA)
Lee, Jinsoo& Son, Kwanghyun& Hwang, Gwi Seo& Kim, Moonju. 2016. Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104067
Modern Language Association (MLA)
Lee, Jinsoo…[et al.]. Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104067
American Medical Association (AMA)
Lee, Jinsoo& Son, Kwanghyun& Hwang, Gwi Seo& Kim, Moonju. Effect and Safety of Shihogyejitang for Drug Resistant Childhood Epilepsy. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104067