A Meta-Analysis of Arsenic Trioxide Combined with Transcatheter Arterial Chemoembolization for Treatment of Primary Hepatic Carcinoma
Joint Authors
Chen, Ruixue
He, Ling
Xu, Qingyun
Chen, Liguo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Primary hepatic carcinoma (PHC) is one of the most common malignant tumours in the world.
More and more research has shown that As2O3 combined with TACE has a good curative effect in treating PHC.
The objectives of this study were to evaluate the therapeutic efficacy and safety of As2O3 combined with TACE in treating PHC.
The CNKI, VIP, Wanfang, PubMed, and Cochrane databases were searched from their inception until December 2015.
Randomized controlled trials (RCTs) comparing As2O3 combined with TACE versus TACE alone in treating PHC were identified.
Stata SE 12.0 was used for data analysis.
17 RCTs with 1055 patients were included.
Meta-analysis showed that, compared with TACE alone, As2O3 combined with TACE showed significant effects in improving the clinical efficacy rate (P<0.01), decreasing the value of alpha-fetoprotein (P<0.01), increasing the one-year survival rate (P<0.01), and improving the quality of life of PHC patients (P<0.01).
Fifteen studies had mentioned adverse events, but no serious adverse effects were reported in any of the included trials.
In conclusion, As2O3 combined with TACE therapy appears to be potentially effective in treating PHC and is generally safe.
However, further studies with rigorous designs trials and multiregional cooperation trials are needed.
American Psychological Association (APA)
He, Ling& Xu, Qingyun& Chen, Liguo& Chen, Ruixue. 2016. A Meta-Analysis of Arsenic Trioxide Combined with Transcatheter Arterial Chemoembolization for Treatment of Primary Hepatic Carcinoma. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104068
Modern Language Association (MLA)
He, Ling…[et al.]. A Meta-Analysis of Arsenic Trioxide Combined with Transcatheter Arterial Chemoembolization for Treatment of Primary Hepatic Carcinoma. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104068
American Medical Association (AMA)
He, Ling& Xu, Qingyun& Chen, Liguo& Chen, Ruixue. A Meta-Analysis of Arsenic Trioxide Combined with Transcatheter Arterial Chemoembolization for Treatment of Primary Hepatic Carcinoma. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104068