DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin
Joint Authors
Rios Santos, Fabrício
Pêgas Henriques, João Antonio
Pungartnik, Cristina
Guecheva, Temenouga Nikolova
Brendel, Martin
Carvalho-Silva, Ronaldo
Pereira, Alanna Cibelle Fernandes
Santos Alves, Rúbens Prince dos
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Garcinia mangostana, popularly known as “mangosteen fruit,” originates from Southeast Asia and came to Brazil about 80 years ago where it mainly grows in the states of Pará and Bahia.
Although mangosteen or its extracts have been used for ages in Asian folk medicine, data on its potential genotoxicity is missing.
We, therefore, evaluated genotoxicity/mutagenicity of hydroethanolic mangosteen extract [HEGM, 10 to 640 μg/mL] in established test assays (Comet assay, micronucleus test, and Salmonella/microsome test).
In the Comet assay, HEGM-exposed human leukocytes showed no DNA damage.
No significant HEGM-induced mutation in TA98 and TA100 strains of Salmonella typhimurium (with or without metabolic activation) was observed and HEGM-exposed human lymphocytes had no increase of micronuclei.
However, HEGM suggested exposure concentration-dependent antigenotoxic potential in leukocytes and antioxidant potential in the yeast Saccharomyces cerevisiae.
HEGM preloading effectively protected against H2O2-induced DNA damage in leukocytes (Comet assay).
Preloading of yeast with HEGM for up to 4 h significantly protected the cells from lethality of chronic H2O2-exposure, as expressed in better survival.
Absence of genotoxicity and demonstration of an antigenotoxic and antioxidant potential suggest that HEGM or some substances contained in it may hold promise for pharmaceutical or nutraceutical application.
American Psychological Association (APA)
Carvalho-Silva, Ronaldo& Pereira, Alanna Cibelle Fernandes& Santos Alves, Rúbens Prince dos& Guecheva, Temenouga Nikolova& Pêgas Henriques, João Antonio& Brendel, Martin…[et al.]. 2016. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104069
Modern Language Association (MLA)
Carvalho-Silva, Ronaldo…[et al.]. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104069
American Medical Association (AMA)
Carvalho-Silva, Ronaldo& Pereira, Alanna Cibelle Fernandes& Santos Alves, Rúbens Prince dos& Guecheva, Temenouga Nikolova& Pêgas Henriques, João Antonio& Brendel, Martin…[et al.]. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104069