Electroacupuncture at ST25 Inhibits Cisapride-Induced Gastric Motility in an Intensity-Dependent Manner
Joint Authors
Pang, Tingting
Lu, Chunxia
Wang, Kaiyue
Liang, Chao
Yu, Zhi
Xu, Bin
Zhu, Bing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Previous studies have demonstrated the efficacy of frequency-specific EAS.
However, evaluation of intensity-response effects is challenging and has yet to be addressed.
Aims.
Using cisapride to promote gastric emptying, we measured the intensity-response relationship of EA at ST25 on gastric motility.
Methods.
We determined the effects of EA at ST25 using intensities (0.5, 1, 3, 5, 7, and 9 mA) on gastric motility in rats injected with cisapride (0.2, 0.02, and 0.002 mg/kg).
Results.
Utilizing three concentrations of cisapride yielded significantly differing levels of gastric motility.
Furthermore, log IC50 values for EAS were different within each group.
Given the same EA intensity, cisapride antagonism decreased progressively in each group as a function of drug concentration.
The relative amount of cisapride antagonized by EAS did not change in a linear fashion.
Finally, EAS at different intensities within the three groups induced a similar pattern of cisapride antagonism.
Conclusions.
The ability of EAS to elicit a decrease in cisapride-induced gastric motility pressure was demonstrated in this study.
The study encompasses construct validity to mirror individualized treatment being based on patients’ subjective feelings, not on a set fixed EA intensity.
Clinically utilizing EAS at the smallest intensity can achieve the desired therapeutic effect.
American Psychological Association (APA)
Pang, Tingting& Lu, Chunxia& Wang, Kaiyue& Liang, Chao& Yu, Zhi& Zhu, Bing…[et al.]. 2016. Electroacupuncture at ST25 Inhibits Cisapride-Induced Gastric Motility in an Intensity-Dependent Manner. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104072
Modern Language Association (MLA)
Pang, Tingting…[et al.]. Electroacupuncture at ST25 Inhibits Cisapride-Induced Gastric Motility in an Intensity-Dependent Manner. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104072
American Medical Association (AMA)
Pang, Tingting& Lu, Chunxia& Wang, Kaiyue& Liang, Chao& Yu, Zhi& Zhu, Bing…[et al.]. Electroacupuncture at ST25 Inhibits Cisapride-Induced Gastric Motility in an Intensity-Dependent Manner. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104072