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Morphine Antidependence of Erythroxylum cuneatum (Miq.) Kurz in Neurotransmission Processes In Vitro
Joint Authors
Basir, Rusliza
Baharuldin, Mohamad Taufik Hidayat Bin
Mohamad Moklas, Mohamad Aris
Suliman, Noor Azuin
Mat Taib, Che Norma
Adenan, Mohd Ilham
Amom, Zulkhairi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Opiate abuse has been studied to cause adaptive changes observed in the presynaptic release and the mediated-synaptic plasticity proteins.
The involvement of neuronal SNARE proteins reveals the role of the neurotransmitter release in expressing the opioid actions.
The present study was designed to determine the effect of the alkaloid extract of Erythroxylum cuneatum (E.
cuneatum) against chronic morphine and the influences of E.
cuneatum on neurotransmission processes observed in vitro.
The human neuroblastoma cell line, SK-N-SH, was treated with the morphine, methadone, or E.
cuneatum.
The cell lysates were collected and tested for α-synuclein, calmodulin, vesicle-associated membrane protein 2 (VAMP 2), and synaptotagmin 1.
The extract of E.
cuneatum was observed to upregulate the decreased expression of dependence proteins, namely, α-synuclein and calmodulin.
The effects were comparable to methadone and control.
The expressions of VAMP 2 and synaptotagmin 1 were normalised by the plant and methadone.
The extract of E.
cuneatum was postulated to treat dependence symptoms after chronic morphine and improve the soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) protein involved in synaptic vesicle after.
American Psychological Association (APA)
Suliman, Noor Azuin& Mohamad Moklas, Mohamad Aris& Mat Taib, Che Norma& Adenan, Mohd Ilham& Baharuldin, Mohamad Taufik Hidayat Bin& Basir, Rusliza…[et al.]. 2016. Morphine Antidependence of Erythroxylum cuneatum (Miq.) Kurz in Neurotransmission Processes In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104078
Modern Language Association (MLA)
Suliman, Noor Azuin…[et al.]. Morphine Antidependence of Erythroxylum cuneatum (Miq.) Kurz in Neurotransmission Processes In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104078
American Medical Association (AMA)
Suliman, Noor Azuin& Mohamad Moklas, Mohamad Aris& Mat Taib, Che Norma& Adenan, Mohd Ilham& Baharuldin, Mohamad Taufik Hidayat Bin& Basir, Rusliza…[et al.]. Morphine Antidependence of Erythroxylum cuneatum (Miq.) Kurz in Neurotransmission Processes In Vitro. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104078