Effect of Catnip Charcoal on the In Vivo Pharmacokinetics of the Main Alkaloids of Rhizoma Coptidis
Joint Authors
Han, Chunyang
He, Yanfei
Liu, Cuiyan
Zhu, Long
Chen, Siyu
Yu, Hai
Liu, Yayun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study aims to explore the effect of catnip Nepeta cataria (CNC) charcoal on the pharmacokinetics of the main alkaloids of Rhizoma Coptidis in vivo.
Twenty-four rabbits were randomly divided into four groups and given oral administration of an aqueous extract of Rhizoma Coptidis (RCAE), RCAE plus CNC, RCAE plus activated carbon (AC), or distilled water, respectively.
Plasma samples were collected after administration.
The concentrations of berberine, coptisine, palmatine, and epiberberine in plasma were measured by high-performance liquid chromatography (HPLC).
The pharmacokinetics data were calculated using pharmacokinetic DAS 2.0 software.
The results showed that the area under the concentration-time curve (AUC) of berberine increased, while the AUC of coptisine, palmatine, and epiberberine decreased in the rabbits that received RCAE plus CNC.
Meanwhile, the AUC of berberine, coptisine, palmatine, and epiberberine decreased in the group given RCAE plus AC.
The difference of main pharmacokinetics parameters among the four groups was significant ( P < 0.05 ).
This study showed that CNC improved the bioavailability of berberine in comparison to AC and prolonged its release in comparison to RCAE alone.
However, it decreased the bioavailability of coptisine, palmatine, and epiberberine.
In comparison, AC uniformly declined the bioavailability of berberine, coptisine, palmatine, and epiberberine.
American Psychological Association (APA)
He, Yanfei& Chen, Siyu& Yu, Hai& Zhu, Long& Liu, Yayun& Han, Chunyang…[et al.]. 2016. Effect of Catnip Charcoal on the In Vivo Pharmacokinetics of the Main Alkaloids of Rhizoma Coptidis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104079
Modern Language Association (MLA)
He, Yanfei…[et al.]. Effect of Catnip Charcoal on the In Vivo Pharmacokinetics of the Main Alkaloids of Rhizoma Coptidis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104079
American Medical Association (AMA)
He, Yanfei& Chen, Siyu& Yu, Hai& Zhu, Long& Liu, Yayun& Han, Chunyang…[et al.]. Effect of Catnip Charcoal on the In Vivo Pharmacokinetics of the Main Alkaloids of Rhizoma Coptidis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104079