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Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review
Joint Authors
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Coelho, Gabriela Diniz Pinto
Martins, Vanessa Soares
Amaral, Laura Vieira do
Sarandy, Mariáurea Matias
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Type II diabetes mellitus is one of the most common public health problems worldwide.
Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention.
The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population.
In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes.
A literature search was performed in MEDLINE/PubMed and Scopus databases.
Studies using other experimental animals (horses, rabbits, and monkeys) and humans as well as articles in Chinese, German, and Russian were excluded.
We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines.
In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol.
In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found.
In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions.
American Psychological Association (APA)
Coelho, Gabriela Diniz Pinto& Martins, Vanessa Soares& Amaral, Laura Vieira do& Novaes, Rômulo Dias& Sarandy, Mariáurea Matias& Gonçalves, Reggiani Vilela. 2016. Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1104080
Modern Language Association (MLA)
Coelho, Gabriela Diniz Pinto…[et al.]. Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-25.
https://search.emarefa.net/detail/BIM-1104080
American Medical Association (AMA)
Coelho, Gabriela Diniz Pinto& Martins, Vanessa Soares& Amaral, Laura Vieira do& Novaes, Rômulo Dias& Sarandy, Mariáurea Matias& Gonçalves, Reggiani Vilela. Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1104080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104080