Systematic Review on Chinese Herbal Medicine Induced Liver Injury
Joint Authors
Zhang, Peng
Ye, Yongan
Yang, Xianzhao
Jiao, Yuntao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
In recent years, with the popularity of CHM, its hepatotoxicity has also been increasingly noticed.
However, there are still veils on causative herbs and clinical characteristics.
Aim.
To systematically review data on CHM induced liver injury with particular focus on causative herbs and clinical characteristics.
Methods.
Using terms related to CHM and liver injury, PubMed and three Chinese electronic databases were searched, which was limited to the past 5 years.
Publications meeting our eligibility criteria were included and further analyzed.
Results.
In total, 4 single herbs, 21 patent drugs, and 4 decoctions were reported to be of hepatotoxicity, with He-Shou-Wu being the most common one (65/114).
Dang-Gui and other 5 herbs were the most common ingredients of patent drugs and decoctions.
All patients were assessed using the RUCAM scale, with 26 being highly probable and 28 being probable.
For these 54 cases, the latent period was 30 (47) days, and 81.48% were labeled as hepatocellular injuries.
Most patients (96.3%) recovered, apart from the fact that one died and one is receiving liver transplantation.
Conclusions.
CHM should be used carefully for hepatotoxicity.
Liver injury from CHM is similar to that from conventional medicines in clinical characteristics.
Details about causative herbs should be illustrated, and more RUCAM should be used in future.
American Psychological Association (APA)
Zhang, Peng& Ye, Yongan& Yang, Xianzhao& Jiao, Yuntao. 2016. Systematic Review on Chinese Herbal Medicine Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104084
Modern Language Association (MLA)
Zhang, Peng…[et al.]. Systematic Review on Chinese Herbal Medicine Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104084
American Medical Association (AMA)
Zhang, Peng& Ye, Yongan& Yang, Xianzhao& Jiao, Yuntao. Systematic Review on Chinese Herbal Medicine Induced Liver Injury. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104084