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Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
Joint Authors
He, Hailang
Xu, Ling
Wang, Dan
Tang, Jie
Zhou, Xian-Mei
Li, Jian-Xin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lung cancer is the leading cause of cancer-related deaths worldwide.
Jin Fu Kang (JFK), an oral liquid prescription of Chinese herbal drugs, has been clinically available for the treatment of non-small cell lung cancer (NSCLC).
Lymphangiogenesis is a primary event in the process of cancer development and metastasis, and the formation and migration of lymphatic endothelial cells (LECs) play a key role in the lymphangiogenesis.
To assess the activity of stromal cell-derived factor-1 (SDF-1) and the coeffect of SDF-1 and vascular endothelial growth factor-C (VEGF-C) on the formation and migration of LECs and clarify the inhibitory effects of JFK on the LECs, the LECs were differentiated from CD34+/VEGFR-3+ endothelial progenitor cells (EPCs), and JFK-containing serums were prepared from rats.
SDF-1 and VEGF-C both induced the differentiation of CD34+/VEGFR-3+ EPCs towards LECs and enhanced the LECs migration.
Couse of SDF-1 and VEGF-C displayed an additive effect on the LECs formation but not on their migration.
JFK inhibited the formation and migration of LECs, and the inhibitory effects were most probably via regulation of the SDF-1/CXCR4 and VEGF-C/VEGFR-3 axes.
The current finding suggested that JFK might inhibit NSCLC through antilymphangiogenesis and also provided a potential to discover antilymphangiogenesis agents from natural resources.
American Psychological Association (APA)
He, Hailang& Wang, Dan& Tang, Jie& Zhou, Xian-Mei& Li, Jian-Xin& Xu, Ling. 2016. Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104091
Modern Language Association (MLA)
He, Hailang…[et al.]. Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104091
American Medical Association (AMA)
He, Hailang& Wang, Dan& Tang, Jie& Zhou, Xian-Mei& Li, Jian-Xin& Xu, Ling. Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104091