Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root of Schoenoplectus grossus
Joint Authors
Subedi, Nirmal Kumar
Rahman, S. M. Abdur
Akbar, Mohammad Ahsanul
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The study aims to evaluate analgesic and antipyretic activities of the methanol extract and its different fractions from root of Schoenoplectus grossus using acetic acid induced writhing and radiant heat tail flick method of pain models in mice and yeast induced pyrexia in rats at the doses of 400 and 200 mg/kg.
In acetic acid writhing test, the methanol extract, petroleum ether, and carbon tetrachloride fractions produced significant (P<0.001 and P<0.05) inhibition of writhing responses in dose dependent manner.
The methanol extract at 400 and 200 mg/kg being more protective with 54% and 45.45% of inhibition compared to diclofenac sodium of 56% followed by petroleum ether fractions of 49.69% and 39.39% at the same doses.
The extracts did not produce any significant antinociceptive activity in tail flick test except standard morphine.
When studied on yeast induced pyrexia, methanol and petroleum ether fractions significantly lowered the rectal temperature time dependently in a manner similar to standard drug paracetamol and distinctly more significant (P<0.001) after second hour.
These findings suggest that the root extracts of S.
grossus possess significant peripherally acting analgesic potential and antipyretic property.
The phytochemical screening showed the presence of flavonoids, alkaloids, and tannins.
American Psychological Association (APA)
Subedi, Nirmal Kumar& Rahman, S. M. Abdur& Akbar, Mohammad Ahsanul. 2016. Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root of Schoenoplectus grossus. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104103
Modern Language Association (MLA)
Subedi, Nirmal Kumar…[et al.]. Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root of Schoenoplectus grossus. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104103
American Medical Association (AMA)
Subedi, Nirmal Kumar& Rahman, S. M. Abdur& Akbar, Mohammad Ahsanul. Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root of Schoenoplectus grossus. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104103