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Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindus indica L.
Joint Authors
Escalona-Arranz, Julio César
Rodriguez Amado, Jesús Rafael
Lafourcade Prada, Ariadna
Pérez Rosés, Renato
Morris Quevedo, Humberto
Keita, Hady
Puente Zapata, Edgar
Carvalho, José Carlos Tavares
Fernandes, Caio Pinho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hepatotoxic chemicals damage liver cells primarily by producing reactive oxygen species.
The decoction of the leaves of Tamarindus indica L.
is used for liver disorders.
In this work we evaluated the hepatoprotective activity of a tablet formulation of this plant.
Thirty-five Sprague Dawley rats were randomly divided into five groups ( n = 7 ).
First group (I) is control group, fed with standard diet.
Groups II to V (hepatotoxic groups) were subjected to a subcutaneous injection of CCl4 (0.5 mL/kg).
Group II was negative control, fed with standard diet; group III was subjected to administration of Silymarin 150 mg/kg and groups IV and V were treated with tablets in dose of 100 mg/kg and 200 mg/kg, respectively.
Lipid peroxidation and the activity of superoxide dismutase, catalase, and reduced glutathione were evaluated.
Serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamine transferase, alkaline phosphatase, and a lipid profile were evaluated too.
The tablets inhibit lipid peroxidation.
The redox balance (SOD-CAT-GSH) remains normal in the experimental groups treated with tablets.
The liver function using dose of 200 mg/kg of tablets was better than the other experimental groups.
These results justify, scientifically, the ethnobotanical use of the leaves of Tamarindus indica L.
American Psychological Association (APA)
Rodriguez Amado, Jesús Rafael& Lafourcade Prada, Ariadna& Escalona-Arranz, Julio César& Pérez Rosés, Renato& Morris Quevedo, Humberto& Keita, Hady…[et al.]. 2016. Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindus indica L.. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104117
Modern Language Association (MLA)
Rodriguez Amado, Jesús Rafael…[et al.]. Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindus indica L.. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104117
American Medical Association (AMA)
Rodriguez Amado, Jesús Rafael& Lafourcade Prada, Ariadna& Escalona-Arranz, Julio César& Pérez Rosés, Renato& Morris Quevedo, Humberto& Keita, Hady…[et al.]. Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindus indica L.. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104117