Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial
Joint Authors
Li, Xiao-jin
Wang, Ru-rong
Kang, Yan
Liu, Jin
Zuo, Yun-xia
Zeng, Xue-feng
Cheng, Gong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the clinical effect of safflower yellow on the treatment of severe sepsis and septic shock.
Methods.
85 patients with severe sepsis and septic shock were randomly selected to receive either therapy according to the international guidelines for management of severe sepsis and septic shock (Surviving Sepsis Campaign 2012) (control group, n = 45) or conventional therapy plus safflower yellow (study group, n = 40).
The 28-day mortality and 28-day Kaplan-Meier survival curves were compared as primary outcomes.
Results.
The 28-day mortality from all causes and in-hospital mortality were significantly lower in the study group (50%, 17.5%) as compared to the control group (78.58%, 54.76%) (P = 0.007, all causes, P < 0.001, in-hospital), and the 28-day Kaplan-Meier survival curve was higher in the study group than in the control group (P = 0.008, all causes, P < 0.001, in-hospital, Log Rank).
72 hours after treatment, secondary outcomes including heart rate, leukocyte counts, lactate levels, and platelet counts of patients in the study group were ameliorated significantly as compared with the control group.
Conclusion.
This study offers a potential new strategy employing safflower yellow to more effectively treat patients with severe sepsis and septic shock.
This trial is registered with identifier ChiCTR-TRC-14005196.
American Psychological Association (APA)
Li, Xiao-jin& Wang, Ru-rong& Kang, Yan& Liu, Jin& Zuo, Yun-xia& Zeng, Xue-feng…[et al.]. 2016. Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104119
Modern Language Association (MLA)
Li, Xiao-jin…[et al.]. Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104119
American Medical Association (AMA)
Li, Xiao-jin& Wang, Ru-rong& Kang, Yan& Liu, Jin& Zuo, Yun-xia& Zeng, Xue-feng…[et al.]. Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104119