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Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla
Joint Authors
Paniagua-Castro, Norma
Soto-García, Marcela
Rosales-Castro, Martha
Escalona-Cardoso, Gerardo N.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Quercus sideroxyla is a wood species whose bark has phenolic compound and should be considered to be bioactive; the hypoglycemic and genotoxic properties of Q.
sideroxyla bark were evaluated in this study.
Total phenolic compound was determined in crude extract (CE) and organic extract (OE).
The OE has the highest amount of phenols ( 724.1 ± 12.0 GAE/g).
Besides, both CE and OE demonstrated effect over the inhibition of α-amylase in vitro.
Hypoglycemic activity was assessed by glucose tolerance curve and the area under curve (UAC); OE showed the highest hypoglycemic activity.
In addition, diabetes was induced by streptozotocin (65 mg/kg) and the extracts (50 mg/kg) were administered for 10 days; OE showed hypoglycemic effect compared with diabetic control and decreased hepatic lipid peroxidation.
Acute toxicity and genotoxicity were evaluated in CE; results of acute toxicity did not show any mortality.
Besides, the comet assay showed that CE at a dose of 100 mg/kg did not show any genotoxic effect when evaluated at 24 h, whereas it induced slight damage at 200 mg/kg, with the formation of type 1 comets.
American Psychological Association (APA)
Soto-García, Marcela& Rosales-Castro, Martha& Escalona-Cardoso, Gerardo N.& Paniagua-Castro, Norma. 2016. Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104124
Modern Language Association (MLA)
Soto-García, Marcela…[et al.]. Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104124
American Medical Association (AMA)
Soto-García, Marcela& Rosales-Castro, Martha& Escalona-Cardoso, Gerardo N.& Paniagua-Castro, Norma. Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104124