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Synergic Effect of Borneol and Ligustrazine on the Neuroprotection in Global Cerebral IschemiaReperfusion Injury: A Region-Specificity Study
Joint Authors
Shen, Xiangchun
Yu, Bin
Ruan, Ming
Zhang, Zhen-Nian
Cheng, Hai-Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The cooperation of ligustrazine (LI) and borneol was proved to be much better than each of them in treating cerebral ischemia.
However, the mechanism of their synergic therapy is unclear till now.
Moreover, whether their cooperation brought different degrees of protection among different brain regions was also unclear.
In the present study, the effects of LI, borneol, and their mixture were observed in global cerebral ischemia-reperfusion (GCIR) injury by detecting microcirculation, expressions of caspase-3 and p53, levels of IL-1β, IL-6, and TNF-α, and contents of SOD, GSH-Px, and MDA in cortex, hippocampus, hypothalamus, and striatum, respectively.
Furthermore, Nissl bodies were scored also.
Monotherapy of LI or borneol showed obvious improvements in the four regions, specially in cortex and hippocampus.
Interestingly, the cooperation of LI and borneol brought some new improvements, specially in hypothalamus and striatum.
Thus, the synergic effect of the two drugs showed region-specificity in GCIR injury except the expressions of caspase-3 and p53.
American Psychological Association (APA)
Yu, Bin& Ruan, Ming& Zhang, Zhen-Nian& Cheng, Hai-Bo& Shen, Xiangchun. 2016. Synergic Effect of Borneol and Ligustrazine on the Neuroprotection in Global Cerebral IschemiaReperfusion Injury: A Region-Specificity Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104126
Modern Language Association (MLA)
Yu, Bin…[et al.]. Synergic Effect of Borneol and Ligustrazine on the Neuroprotection in Global Cerebral IschemiaReperfusion Injury: A Region-Specificity Study. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104126
American Medical Association (AMA)
Yu, Bin& Ruan, Ming& Zhang, Zhen-Nian& Cheng, Hai-Bo& Shen, Xiangchun. Synergic Effect of Borneol and Ligustrazine on the Neuroprotection in Global Cerebral IschemiaReperfusion Injury: A Region-Specificity Study. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104126