Qingchang Wenzhong Decoction Ameliorates Dextran Sulphate Sodium-Induced Ulcerative Colitis in Rats by Downregulating the IP10CXCR3 Axis-Mediated Inflammatory Response
Joint Authors
Li, Junxiang
Guo, Yi
Zhao, Wei-han
Mao, Tang-you
Shi, Rui
Gao, Kang-li
Chen, Chen
Xie, Tian-hong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Qingchang Wenzhong Decoction (QCWZD) is an effective traditional Chinese medicine prescription.
Our previous studies have shown that QCWZD has significant efficacy in patients with mild-to-moderate ulcerative colitis (UC) and in colonic mucosa repair in UC rat models.
However, the exact underlying mechanism remains unknown.
Thus, this study was conducted to determine QCWZD’s efficacy and mechanism in dextran sulphate sodium- (DSS-) induced UC rat models, which were established by 7-day administration of 4.5% DSS solution.
QCWZD was administered daily for 7 days, after which the rats were euthanized.
Disease activity index (DAI), histological score (HS), and myeloperoxidase (MPO) level were determined to evaluate UC severity.
Serum interferon gamma-induced protein 10 (IP10) levels were determined using ELISA kits.
Western blotting and real-time polymerase chain reaction were, respectively, used to determine colonic protein and gene expression of IP10, chemokine (cys-x-cys motif) receptor (CXCR)3, and nuclear factor- (NF-) κB p65.
Intragastric QCWZD administration ameliorated DSS-induced UC, as evidenced by decreased DAI, HS, and MPO levels.
Furthermore, QCWZD decreased the protein and gene expression of IP10, CXCR3, and NF-κB p65.
Overall, these results suggest that QCWZD ameliorates DSS-induced UC in rats by downregulating the IP10/CXCR3 axis-mediated inflammatory response and may be a novel UC therapy.
American Psychological Association (APA)
Mao, Tang-you& Shi, Rui& Zhao, Wei-han& Guo, Yi& Gao, Kang-li& Chen, Chen…[et al.]. 2016. Qingchang Wenzhong Decoction Ameliorates Dextran Sulphate Sodium-Induced Ulcerative Colitis in Rats by Downregulating the IP10CXCR3 Axis-Mediated Inflammatory Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104140
Modern Language Association (MLA)
Mao, Tang-you…[et al.]. Qingchang Wenzhong Decoction Ameliorates Dextran Sulphate Sodium-Induced Ulcerative Colitis in Rats by Downregulating the IP10CXCR3 Axis-Mediated Inflammatory Response. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104140
American Medical Association (AMA)
Mao, Tang-you& Shi, Rui& Zhao, Wei-han& Guo, Yi& Gao, Kang-li& Chen, Chen…[et al.]. Qingchang Wenzhong Decoction Ameliorates Dextran Sulphate Sodium-Induced Ulcerative Colitis in Rats by Downregulating the IP10CXCR3 Axis-Mediated Inflammatory Response. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104140