Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells
Joint Authors
Pongrakhananon, Varisa
Sritularak, Boonchoo
Chanvorachote, Pithi
Unahabhokha, Thitita
Kitsongsermthon, Jutarat
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lung cancer remains a leading public health problem as evidenced by its increasing death rate.
The main cause of death in lung cancer patients is cancer metastasis.
The metastatic behavior of lung cancer cells becomes enhanced when cancer cells undergo epithelial to mesenchymal transition (EMT).
Gigantol, a bibenzyl compound extracted from the Thai orchid, Dendrobium draconis, has been shown to have promising therapeutic potential against cancer cells, which leads to the hypothesis that gigantol may be able to inhibit the fundamental EMT process in cancer cells.
This study has demonstrated for the first time that gigantol possesses the ability to suppress EMT in non-small cell lung cancer H460 cells.
Western blot analysis has revealed that gigantol attenuates the activity of ATP-dependent tyrosine kinase (AKT), thereby inhibiting the expression of the major EMT transcription factor, Slug, by both decreasing its transcription and increasing its degradation.
The inhibitory effects of gigantol on EMT result in a decrease in the level of migration in H460 lung cancer cells.
The results of this study emphasize the potential of gigantol for further development against lung cancer metastasis.
American Psychological Association (APA)
Unahabhokha, Thitita& Chanvorachote, Pithi& Sritularak, Boonchoo& Kitsongsermthon, Jutarat& Pongrakhananon, Varisa. 2016. Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104153
Modern Language Association (MLA)
Unahabhokha, Thitita…[et al.]. Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104153
American Medical Association (AMA)
Unahabhokha, Thitita& Chanvorachote, Pithi& Sritularak, Boonchoo& Kitsongsermthon, Jutarat& Pongrakhananon, Varisa. Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104153