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Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats
Joint Authors
Aldawsari, Hibah
Hanafy, Abeer
Badr, Jihan M.
Ibrahim, Amany K.
Abdel-Hady, Seham El-Sayed
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The methanol extract of the fruit pulp of Adansonia digitata L.
(Malvaceae) was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats.
The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress.
In addition, hepatospecific serum markers will be disturbed.
Treatment of the rats with the methanol extract of the fruit pulp of Adansonia digitata L.
prior to administration of acetaminophen significantly reduced the disturbance in liver function.
Liver functions were measured by assessment of total protein, total bilirubin, ALP, ALT, and AST.
Oxidative stress parameter and antioxidant markers were also evaluated.
Moreover, histopathological evaluation was performed in order to assess liver case regarding inflammatory infiltration or necrosis.
Animals were observed for any symptoms of toxicity after administration of extract of the fruit pulp of Adansonia digitata L.
to ensure safety of the fruit extract.
American Psychological Association (APA)
Hanafy, Abeer& Aldawsari, Hibah& Badr, Jihan M.& Ibrahim, Amany K.& Abdel-Hady, Seham El-Sayed. 2016. Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104154
Modern Language Association (MLA)
Hanafy, Abeer…[et al.]. Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104154
American Medical Association (AMA)
Hanafy, Abeer& Aldawsari, Hibah& Badr, Jihan M.& Ibrahim, Amany K.& Abdel-Hady, Seham El-Sayed. Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104154