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Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective
Joint Authors
Wang, Ning
Tan, Hor Yue
Wen, Xiao-Yan
Hong, Ming
Li, Lei
Cheung, Fan
San-Marina, Serban
Li, Sha
Feng, Yibin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
Liver disease results from a dynamic pathological process associated with cellular and genetic alterations, which may progress stepwise to liver dysfunction.
Commonly, liver disease begins with hepatocyte injury, followed by persistent episodes of cellular regeneration, inflammation, and hepatocyte death that may ultimately lead to nonreversible liver failure.
For centuries, herbal remedies have been used for a variety of liver diseases and recent studies have identified the active compounds that may interact with liver disease-associated targets.
Further study on the herbal remedies may lead to the formulation of next generation medicines with hepatoprotective, antifibrotic, and anticancer properties.
Still, the pharmacological actions of vast majority of herbal remedies remain unknown; thus, extensive preclinical studies are important.
In this review, we summarize progress made over the last five years of the most commonly used preclinical models of liver diseases that are used to screen for curative herbal medicines for nonalcoholic fatty liver disease, liver fibrosis/cirrhosis, and liver.
We also summarize the proposed mechanisms associated with the observed liver-protective, antifibrotic, and anticancer actions of several promising herbal medicines and discuss the challenges faced in this research field.
American Psychological Association (APA)
Tan, Hor Yue& San-Marina, Serban& Wang, Ning& Hong, Ming& Li, Sha& Li, Lei…[et al.]. 2016. Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1104169
Modern Language Association (MLA)
Tan, Hor Yue…[et al.]. Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-26.
https://search.emarefa.net/detail/BIM-1104169
American Medical Association (AMA)
Tan, Hor Yue& San-Marina, Serban& Wang, Ning& Hong, Ming& Li, Sha& Li, Lei…[et al.]. Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-26.
https://search.emarefa.net/detail/BIM-1104169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104169