The Induction of Apoptosis in A375 Malignant Melanoma Cells by Sutherlandia frutescens
Joint Authors
van der Walt, Nicola B.
Cronjé, Marianne J.
Zakeri, Zahra
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Sutherlandia frutescens is a medicinal plant indigenous to Southern Africa and is commonly known as the “cancer bush.” This plant has traditionally been used for the treatment of various ailments, although it is best known for its claims of activity against “internal” cancers.
Here we report on its effect on melanoma cells.
The aim of this study was to investigate whether an extract of S.
frutescens could induce apoptosis in the A375 melanoma cell line and to outline the basic mechanism of action.
S.
frutescens extract induced apoptosis in A375 cells as evidenced by morphological features of apoptosis, phosphatidylserine exposure, nuclear condensation, caspase activation, and the release of cytochrome c from the mitochondria.
Studies in the presence of a pan-caspase inhibitor allude to caspase-independent cell death, which appeared to be mediated by the apoptosis inducing factor.
Taken together, the results of this study show that S.
frutescens extract is effective in inducing apoptosis in malignant melanoma cells and indicates that further in vivo mechanistic studies may be warranted.
American Psychological Association (APA)
van der Walt, Nicola B.& Zakeri, Zahra& Cronjé, Marianne J.. 2016. The Induction of Apoptosis in A375 Malignant Melanoma Cells by Sutherlandia frutescens. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1104173
Modern Language Association (MLA)
van der Walt, Nicola B.…[et al.]. The Induction of Apoptosis in A375 Malignant Melanoma Cells by Sutherlandia frutescens. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1104173
American Medical Association (AMA)
van der Walt, Nicola B.& Zakeri, Zahra& Cronjé, Marianne J.. The Induction of Apoptosis in A375 Malignant Melanoma Cells by Sutherlandia frutescens. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1104173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104173