Acute and Subacute Toxicological Evaluation of the Aerial Extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar Rats

Joint Authors

Wintola, O. A.
Fouche, Gerda
Afolayan, Anthony Jide

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-09-08

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

The acute and subacute toxicity profile of the aerial extract of Monsonia angustifolia in Wistar rats was evaluated.

The Organization for Economic Cooperation and Development (OECD) 420 guideline was adopted in the acute toxicity testing with a single oral dose of 5000 mg/kg (b.w.).

For the 28-day daily oral dosing, the extract was administered at 75, 150, and 300 mg/kg b.w.; 1% ethanol in sterile distilled water was used as control.

Clinical toxicity signs were subsequently evaluated.

At a single dose of 5000 mg/kg b.w.

the extract elicited no treatment-related signs of toxicity in the animals during the 14 days of experimental period.

In the subacute toxicity, there was no significant difference in hematological, renal, and liver function indices.

However, dose-dependent significant increases were observed on the plasma concentrations of white blood cell and platelet counts of the treated animals compared to the control group.

While cage observations revealed no treatment-facilitated signs of toxicity, histopathological examinations of the kidneys and liver also showed no obvious lesions and morphological changes.

These results suggest that the extract may be labelled and classified as safe and practically nontoxic within the doses and period of investigation in this study.

American Psychological Association (APA)

Afolayan, Anthony Jide& Wintola, O. A.& Fouche, Gerda. 2016. Acute and Subacute Toxicological Evaluation of the Aerial Extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104176

Modern Language Association (MLA)

Afolayan, Anthony Jide…[et al.]. Acute and Subacute Toxicological Evaluation of the Aerial Extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104176

American Medical Association (AMA)

Afolayan, Anthony Jide& Wintola, O. A.& Fouche, Gerda. Acute and Subacute Toxicological Evaluation of the Aerial Extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104176

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1104176