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Effects of Cymbidium Root Ethanol Extract on Atopic Dermatitis
Joint Authors
Kim, T.-J.
Kim, Wan-Joong
Cha, Hae-Sim
Lee, Myung-Hun
Kim, Sun-Young
Kim, Seo Ho
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cymbidium has known antibacterial and antiedema activity and has been used as an ingredient in cosmetics and fragrances.
The effects of Cymbidium ethanol extract (CYM) on allergic response and the underlying mechanisms of action have not been reported.
Therefore, the purpose of this study was to determine the effect of CYM on allergic responses.
Topical application of CYM was effective against immunoglobulin E (IgE)/dinitrophenyl-conjugated bovine serum albumin- (DNP-BSA-) induced degranulation of RBL-2H3 cells and anaphylaxis in ICR mice.
An allergic dermatitis-like mouse model was used to evaluate the therapeutic potential of CYM in vivo.
Continuous application of 2,4-dinitrochlorobenzene (DNCB) not only induced dermatitis in ICR mice but also aggravated the skin lesioning.
However, the application of CYM decreased skin lesion severity, scratching behavior, and IgE levels.
In addition, CYM downregulated the expression of the proinflammatory cytokines interleukin- (IL-) 4, IL-13, and tumor necrosis factor- (TNF-) α.
Studies of signal transduction pathways showed that CYM suppressed the phosphorylation of spleen tyrosine kinase (Syk), an upstream molecule.
It also inhibited the phosphorylation of Akt, phospholipase C- (PLC-) γ, and mitogen-activated protein kinase kinase kinase (MEKK).
These results indicate that CYM may be effective in preventing and reducing allergic response and may have therapeutic potential as an antiallergic agent in disorders such as atopic dermatitis.
American Psychological Association (APA)
Kim, Wan-Joong& Cha, Hae-Sim& Lee, Myung-Hun& Kim, Sun-Young& Kim, Seo Ho& Kim, T.-J.. 2016. Effects of Cymbidium Root Ethanol Extract on Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104206
Modern Language Association (MLA)
Kim, Wan-Joong…[et al.]. Effects of Cymbidium Root Ethanol Extract on Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104206
American Medical Association (AMA)
Kim, Wan-Joong& Cha, Hae-Sim& Lee, Myung-Hun& Kim, Sun-Young& Kim, Seo Ho& Kim, T.-J.. Effects of Cymbidium Root Ethanol Extract on Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104206