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Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7NF-κB Pathway
Joint Authors
Gu, Meng
Zheng, Ai-bin
Jin, Jing
Cui, Yue
Zhang, Ning
Che, Zhi-ping
Wang, Yan
Zhan, Jie
Tu, Wen-juan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study aimed to assess the effects and mechanisms of genistin in the rat model of myocardial ischemia reperfusion injury.
The rat hearts were exposed to the left anterior descending coronary artery (LAD) ligation for 30 min followed by 1 h of reperfusion.
In the rat of myocardial ischemia/reperfusion (MI/R), it was found that genistin pretreatment reduced myocardial infarct size, improved the heart rate, and decreased creatine kinase (CK) and lactate dehydrogenase (LDH) levels in coronary flow.
This pretreatment also increased catalase (CAT), superoxide dismutase (SOD) activities but decreased glutathione (GSH), malondialdehyde (MDA) levels.
Furthermore, we determined that genistin can ameliorate the impaired mitochondrial morphology and oxidation system; interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) levels were also recovered.
Besides, related-proteins of nuclear factor kappa-B (NF-κB) signal pathway activated by P2X7 were investigated to determine the molecular mechanism of genistin and their expressions were measured by western blot.
These results presented here demonstrated that genistin enhanced the protective effect on the rats with myocardial ischemia reperfusion injury.
Therefore, the cardioprotective effects of genistin may rely on its antioxidant and anti-inflammatory activities via suppression of P2X7/NF-κB pathways.
American Psychological Association (APA)
Gu, Meng& Zheng, Ai-bin& Jin, Jing& Cui, Yue& Zhang, Ning& Che, Zhi-ping…[et al.]. 2016. Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104208
Modern Language Association (MLA)
Gu, Meng…[et al.]. Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104208
American Medical Association (AMA)
Gu, Meng& Zheng, Ai-bin& Jin, Jing& Cui, Yue& Zhang, Ning& Che, Zhi-ping…[et al.]. Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104208