In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation
Joint Authors
Tomczyk, Michał
Grochowski, Daniel Mirosław
Paduch, Roman
Wiater, Adrian
Dudek, Adrianna
Pleszczyńska, Małgorzata
Tomczykowa, Monika
Granica, Sebastian
Polak, Paulina
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was performed to evaluate the effect of different extracts and subfractions from Rubus caesius leaves on two human colon cancer cell lines obtained from two stages of the disease progression lines HT29 and SW948.
Tested samples inhibited the viability of cells, both HT29 and SW948 lines, in a concentration-dependent manner.
The most active was the ethyl acetate fraction which, applied at the highest concentration (250 μg/mL), decreased the viability of cells (HT29 and SW948) below 66%.
The extracts and subfractions were also investigated for antioxidant activities on DPPH and FRAP assays.
All extracts, with the exception of water extract at a dose of 250 μg/mL, almost totally reduced DPPH.
The highest Fe3+ ion reduction was shown for the diethyl and ethyl acetate fractions.
It was more than 6.5 times higher (at a dose 250 μg/mL) as compared to the control.
The LC-MS studies of the analysed preparations showed that all samples contain a wide variety of polyphenolics, among which ellagitannins turned out to be the main constituents with dominant ellagic acid, sanguiin H-6, and flavonol derivatives.
American Psychological Association (APA)
Grochowski, Daniel Mirosław& Paduch, Roman& Wiater, Adrian& Dudek, Adrianna& Pleszczyńska, Małgorzata& Tomczykowa, Monika…[et al.]. 2016. In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104223
Modern Language Association (MLA)
Grochowski, Daniel Mirosław…[et al.]. In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104223
American Medical Association (AMA)
Grochowski, Daniel Mirosław& Paduch, Roman& Wiater, Adrian& Dudek, Adrianna& Pleszczyńska, Małgorzata& Tomczykowa, Monika…[et al.]. In Vitro Antiproliferative and Antioxidant Effects of Extracts from Rubus caesius Leaves and Their Quality Evaluation. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104223