Anti-Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Inflammation plays a crucial role in the pathophysiology of acute ischemic stroke.
In the ischemic cascade, resident microglia are rapidly activated in the brain parenchyma and subsequently trigger inflammatory mediator release, which facilitates leukocyte-endothelial cell interactions in inflammation.
Activated leukocytes invade the endothelial cell junctions and destroy the blood-brain barrier integrity, leading to brain edema.
Toll-like receptors (TLRs) stimulation in microglia/macrophages through the activation of intercellular signaling pathways secretes various proinflammatory cytokines and enzymes and then aggravates cerebral ischemic injury.
The secreted cytokines activate the proinflammatory transcription factors, which subsequently regulate cytokine expression, leading to the amplification of the inflammatory response and exacerbation of the secondary brain injury.
Traditional Chinese medicines (TCMs), including TCM-derived active compounds, Chinese herbs, and TCM formulations, exert neuroprotective effects against inflammatory responses by downregulating the following: ischemia-induced microglial activation, microglia/macrophage-mediated cytokine production, proinflammatory enzyme production, intercellular adhesion molecule-1, matrix metalloproteinases, TLR expression, and deleterious transcription factor activation.
TCMs also aid in upregulating anti-inflammatory cytokine expression and neuroprotective transcription factor activation in the ischemic lesion in the inflammatory cascade during the acute phase of cerebral ischemia.
Thus, TCMs exert potent anti-inflammatory properties in ischemic stroke and warrant further investigation.
American Psychological Association (APA)
Cheng, Chin-Yi& Lee, Yu-Chen. 2016. Anti-Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1104226
Modern Language Association (MLA)
Cheng, Chin-Yi& Lee, Yu-Chen. Anti-Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1104226
American Medical Association (AMA)
Cheng, Chin-Yi& Lee, Yu-Chen. Anti-Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1104226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104226