Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice
Joint Authors
Zhu, Yingli
Wang, Linyuan
Yang, Zhihui
Wang, Jingxia
Li, Wei
Zhou, Jianyu
Zhang, Jianjun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Paeonia lactiflora root (baishao in Chinese) is a commonly used herb in traditional Chinese medicine (TCM).
Paeoniflorin (PF) and albiflorin (AF) are two major active constituents of P.
lactiflora.
In this paper, we aimed to investigate the hematopoietic effects of PF and AF on myelosuppression mice induced by radiotherapy and to explore the underlying mechanism.
The finding indicated that PF and AF significantly increased the numbers of white blood cells (WBC) and reversed the atrophy of thymus.
Furthermore, PF and AF increased the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) and reduced the levels of tumor necrosis factor-α (TNF-α) in serum and increased the level of colony-stimulating factor (G-CSF) in plasma.
Lastly, PF and AF not only enhanced the mRNA levels of GM-CSF and G-CSF in the spleens, but also increased the protein levels of G-CSF and GM-CSF in bone marrow.
Our results suggest that PF and AF may promote the recovery of bone marrow hemopoietic function in a myelosuppressed mouse model.
American Psychological Association (APA)
Zhu, Yingli& Wang, Linyuan& Yang, Zhihui& Wang, Jingxia& Li, Wei& Zhou, Jianyu…[et al.]. 2016. Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104229
Modern Language Association (MLA)
Zhu, Yingli…[et al.]. Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104229
American Medical Association (AMA)
Zhu, Yingli& Wang, Linyuan& Yang, Zhihui& Wang, Jingxia& Li, Wei& Zhou, Jianyu…[et al.]. Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104229