The Efficacy of Brucea javanica Oil Emulsion Injection as Adjunctive Therapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis
Joint Authors
Xu, Wei
Jiang, Xinchan
Xu, Zhengyuan
Ye, Tong
Shi, Qionghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To evaluate the efficacy of Brucea javanica oil emulsion injection (BJOEI) in patients with advanced non-small-cell lung cancer (NSCLC) during chemotherapy.
Method.
Electronic database of EMBASE and PubMed and the conference proceeding of ASCO, CNKI, CBMdisc, VIP, and Wanfang database were searched to select RCTs comparing BJOEI plus chemotherapy with chemotherapy alone in the treatment of advanced NSCLC, until June 1, 2016.
Two reviewers independently performed the analysis according to the inclusion and exclusion criteria.
Review Manager 5.3 and STATA 12.0 were employed for data analysis.
Result.
Twenty-one studies including 2234 cases were included.
The pooled result indicated that there were significant differences in ORR (RR=1.25; 95% CI: 1.14–1.36; P<0.00001), improvement of QOL (RR=1.87; 95% CI: 1.63–2.15; P<0.00001), nausea and vomiting (RR=0.67; 95% CI: 0.46–0.98; P=0.04), leukopenia (RR=0.63; 95% CI: 0.52–0.75; P<0.00001), but there was no difference in thrombocytopenia (RR=0.78; 95% CI: 0.49–1.23; P=0.29).
Begg’s funnel plot and Egger’s test indicated that no publication bias was found.
The sensitivity analysis suggested the stability of the pooled result.
Conclusion.
The addition of BJOEI can enhance efficacy, improve QOL, and decrease incidence of nausea and vomiting and leukopenia for advanced NSCLC patients.
However, higher quality RCTs are needed to further confirm this finding.
American Psychological Association (APA)
Xu, Wei& Jiang, Xinchan& Xu, Zhengyuan& Ye, Tong& Shi, Qionghua. 2016. The Efficacy of Brucea javanica Oil Emulsion Injection as Adjunctive Therapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104241
Modern Language Association (MLA)
Xu, Wei…[et al.]. The Efficacy of Brucea javanica Oil Emulsion Injection as Adjunctive Therapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104241
American Medical Association (AMA)
Xu, Wei& Jiang, Xinchan& Xu, Zhengyuan& Ye, Tong& Shi, Qionghua. The Efficacy of Brucea javanica Oil Emulsion Injection as Adjunctive Therapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104241