A Novel Method for Evaluating the Cardiotoxicity of Traditional Chinese Medicine Compatibility by Using Support Vector Machine Model Combined with Metabonomics
Joint Authors
Li, Yu-bo
Zhang, Yanjun
Zhou, Haonan
Xie, Jiabin
Ally, Mayassa Salum
Hou, Zhiguo
Xu, Yanyan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Traditional biochemical and histopathological tests have been used to evaluate the safety of traditional Chinese medicine (TCM) compatibility for a long time.
But these methods lack high sensitivity and specificity.
In the previous study, we have found ten biomarkers related to cardiotoxicity and established a support vector machine (SVM) prediction model.
Results showed a good sensitivity and specificity.
Therefore, in this study, we used SVM model combined with metabonomics UPLC/Q-TOF-MS technology to build a rapid and sensitivity and specificity method to predict the cardiotoxicity of TCM compatibility.
This study firstly applied SVM model to the prediction of cardiotoxicity in TCM compatibility containing Aconiti Lateralis Radix Praeparata and further identified whether the cardiotoxicity increased after Aconiti Lateralis Radix Praeparata combined with other TCM.
This study provides a new idea for studying the evaluation of the cardiotoxicity caused by compatibility of TCM.
American Psychological Association (APA)
Li, Yu-bo& Zhou, Haonan& Xie, Jiabin& Ally, Mayassa Salum& Hou, Zhiguo& Xu, Yanyan…[et al.]. 2016. A Novel Method for Evaluating the Cardiotoxicity of Traditional Chinese Medicine Compatibility by Using Support Vector Machine Model Combined with Metabonomics. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104253
Modern Language Association (MLA)
Li, Yu-bo…[et al.]. A Novel Method for Evaluating the Cardiotoxicity of Traditional Chinese Medicine Compatibility by Using Support Vector Machine Model Combined with Metabonomics. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104253
American Medical Association (AMA)
Li, Yu-bo& Zhou, Haonan& Xie, Jiabin& Ally, Mayassa Salum& Hou, Zhiguo& Xu, Yanyan…[et al.]. A Novel Method for Evaluating the Cardiotoxicity of Traditional Chinese Medicine Compatibility by Using Support Vector Machine Model Combined with Metabonomics. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104253