Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose
Joint Authors
Chen, Hui
Long, Yuanyuan
Guo, Lei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The antiaging effect of Inula britannica flower total flavonoids (IBFTF) on aging mice induced by D-galactose and its mechanism was examined in this study.
From the results, the biochemical indexes and histological analysis of skin tissues showed that IBFTF could effectively improve the antioxidant enzyme activity of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of skin tissue, and decrease the malondialdehyde (MDA) content.
Besides, IBFTF could maintain the skin collagen, hydroxyproline (Hyp), dermal thickness, and moisture content.
Meanwhile, IBFTF could significantly reduce the number of cells arrested in G0/G1 phase, and from the point of view of protein and mRNA expression level in skin tissue, IBFTF could significantly increase the expression of Sirt1 and CyclinD1 but decrease the expression of p16 and p21, and its effect was not less than that of the well-known vitamin E (VE).
Overall, these results seem to be implying that IBFTF is a potential natural anti-skin aging agent with great antioxidant ability.
American Psychological Association (APA)
Chen, Hui& Long, Yuanyuan& Guo, Lei. 2016. Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104257
Modern Language Association (MLA)
Chen, Hui…[et al.]. Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104257
American Medical Association (AMA)
Chen, Hui& Long, Yuanyuan& Guo, Lei. Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104257