Inhibitory Effects of Angelica Polysaccharide on Activation of Mast Cells
Joint Authors
Mao, Wei-An
Sun, Yuan-Yuan
Mao, Jing-Yi
Wang, Li
Zhang, Jian
Zhou, Jie
Ye, Ying
Rahman, Khalid
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was designed to investigate the inhibitory effects of Angelica polysaccharide (AP) on activation of mast cells and its possible molecular mechanism.
In our study, we determined the proinflammatory cytokines and allergic mediators in anti-DNP IgE stimulated RBL-2H3 cells and found that AP (50, 100, and 200 μg/mL) significantly decreased the release of histamine, β-hexosaminidase, leukotrienes C4 (LTC4), IL-1, IL-4, TNF-α, IL-6, and human monocyte chemotactic protein-1 (MCP-1/CCL2) ( p < 0.05 ).
In addition, Ca2+ entry was inhibited by treatment with AP.
AP also downregulated the protein expressions of p-Fyn, p-Akt, p-P38, IL-4, TNF-α, and NF-κB p65 in both Fyn gene upregulated and normal RBL-2H3 cells ( p < 0.05 ).
Collectively, our results showed that AP could inhibit the activation of mast cells via suppressing the releases of proinflammatory cytokines allergic mediators, Gab2/PI3-K/Akt and Fyn/Syk pathways.
American Psychological Association (APA)
Mao, Wei-An& Sun, Yuan-Yuan& Mao, Jing-Yi& Wang, Li& Zhang, Jian& Zhou, Jie…[et al.]. 2016. Inhibitory Effects of Angelica Polysaccharide on Activation of Mast Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104260
Modern Language Association (MLA)
Mao, Wei-An…[et al.]. Inhibitory Effects of Angelica Polysaccharide on Activation of Mast Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104260
American Medical Association (AMA)
Mao, Wei-An& Sun, Yuan-Yuan& Mao, Jing-Yi& Wang, Li& Zhang, Jian& Zhou, Jie…[et al.]. Inhibitory Effects of Angelica Polysaccharide on Activation of Mast Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104260