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Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma
Joint Authors
Mukudai, Yoshiki
Zhang, Meilin
Shiogama, Sunao
Kondo, Seiji
Ito, Chihiro
Motohashi, Hiromi
Kato, Kosuke
Fujii, Miharu
Shintani, Satoru
Shigemori, Hideyuki
Yazawa, Kazunaga
Shirota, Tatsuo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Squamous cell carcinoma (SCC) is one of the most common cancers of the head and neck region worldwide and is generally treated surgically in combination with radiotherapy and/or chemotherapy.
However, anticancer agents have numerous serious side effects, and alternative, less toxic agents that are effective as chemotherapeutics for SCC are required.
The Paeoniaceae family is widely used in traditional Chinese medicine.
We examined methanol and butanol extracts of Paeonia lutea (P.
lutea) leaves for their potential as an anticancer agent.
Both extracts decreased the proliferation of SCC cells, induced apoptotic cell death, and modulated migration, adhesion, chemotaxis, and haptotaxis in an extracellular matrix- (ECM-) dependent manner due to altered expression of several integrin subunits.
Subsequently, SCC cells were subcutaneously transplanted into athymic nude mice; the extracts reduced the metastasis of SCC cells but had little effect on the volume of the primary tumor or survival or body weight of the mice.
The results suggest that the extracts may hold promise for preventing cancer metastasis.
American Psychological Association (APA)
Mukudai, Yoshiki& Zhang, Meilin& Shiogama, Sunao& Kondo, Seiji& Ito, Chihiro& Motohashi, Hiromi…[et al.]. 2016. Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104264
Modern Language Association (MLA)
Mukudai, Yoshiki…[et al.]. Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104264
American Medical Association (AMA)
Mukudai, Yoshiki& Zhang, Meilin& Shiogama, Sunao& Kondo, Seiji& Ito, Chihiro& Motohashi, Hiromi…[et al.]. Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104264