In Vivo Evaluation of the Anti-Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress
Joint Authors
Ben Khedir, Sameh
Mzid, Masarra
Bardaa, Sana
Moalla, Dorsaf
Sahnoun, Zouheir
Rebai, Tarek
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In order to find new topical anti-inflammatory agents, we had recourse to a medicinal plant.
This work was designed to determine the topical anti-inflammatory effect of Pistacia lentiscus fruit oil (PLFO), using carrageenan-induced paw edema rat model, and to evaluate its effects on oxidative stress.
The topical anti-inflammatory activity of PLFO was compared to Inflocine® and estimated by measuring the diameter of paw edema, for 5 hours at a 1-hour interval.
After that the rats were scarified and the inflamed paw tissue was removed for the exploration of some parameters of oxidative stress and histopathology.
PLFO showed a significant anti-inflammatory activity in comparison with the Inflocine.
The percentages of edema inhibition were 70% and % 51.5% (p<0.01), respectively, after five hours.
The treatment with PLFO and Inflocine led to significant increases (p≤0.05) in the activities of CAT, SOD, and GPX and significant decreases in the MDA level and AOPP activity in the paw tissue after Carr injection, in comparison with the Carr group.
Therefore, our findings demonstrate that PLFO might accelerate the development of new drugs which could be used scientifically as a source for natural health products in the treatment of topical inflammation.
American Psychological Association (APA)
Ben Khedir, Sameh& Mzid, Masarra& Bardaa, Sana& Moalla, Dorsaf& Sahnoun, Zouheir& Rebai, Tarek. 2016. In Vivo Evaluation of the Anti-Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104266
Modern Language Association (MLA)
Ben Khedir, Sameh…[et al.]. In Vivo Evaluation of the Anti-Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104266
American Medical Association (AMA)
Ben Khedir, Sameh& Mzid, Masarra& Bardaa, Sana& Moalla, Dorsaf& Sahnoun, Zouheir& Rebai, Tarek. In Vivo Evaluation of the Anti-Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104266