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Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice
Joint Authors
Ma, Choong Je
Jung, Youn Sik
Kim, Nam Young
Kim, Myong Ki
Weon, Jin Bae
Lee, Hyeon Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aronia melanocarpa (A.
melanocarpa) berries are a fruit with a marked antioxidant effect.
The objective of this study was to confirm the effect of A.
melanocarpa berries extract against scopolamine-induced memory impairment in mice using the Morris water maze and passive avoidance test.
Moreover, we determined a possible mechanism of the cognitive-enhancing effect involving AChE activity and BDNF and p-CREB expression in the hippocampus of mice.
A.
melanocarpa berries extract attenuated the learning and memory impairment induced by scopolamine in the Morris water maze (79.3 ± 0.8 s of 200 mg/kg and 64.4 ± 10.7 s of 400 mg/kg on day 4) and passive avoidance tests (46.0 ± 41.1 s of 200 mg/kg and 25.6 ± 18.7 s of 400 mg/kg).
A.
melanocarpa berries extract reduced the acetylcholinesterase level in the hippocampus of scopolamine-injected mice and increased BDNF and p-CREB expression in the hippocampus.
The major compound, cyanidin-3-O-galactoside, also reversed memory impairment.
These results showed that A.
melanocarpa berries extract improved memory impairment by inhibiting AChE and increasing BDNF and p-CREB expression, and cyanidin-3-O-galactoside may be responsible for the effect of A.
melanocarpa berries extract.
American Psychological Association (APA)
Lee, Hyeon Yong& Weon, Jin Bae& Jung, Youn Sik& Kim, Nam Young& Kim, Myong Ki& Ma, Choong Je. 2016. Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104268
Modern Language Association (MLA)
Lee, Hyeon Yong…[et al.]. Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104268
American Medical Association (AMA)
Lee, Hyeon Yong& Weon, Jin Bae& Jung, Youn Sik& Kim, Nam Young& Kim, Myong Ki& Ma, Choong Je. Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104268