Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model
Joint Authors
Ai-Ming, Wu
Dong, Bin
Nie, Bo
Li, Xue
Wei, Yi
Chen, Meng
Zhou, Jingwei
Zhao, Jiuli
Zhu, Lingqun
Chai, Limin
Li-Xia, Lou
Zhang, Dong-mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In traditional Chinese medicine (TCM), xianfanghuomingyin (XFHM) is used to treat autoimmune diseases, including rheumatoid arthritis (RA).
Here, we studied the mechanisms underlying its treatment effects, especially its anti-inflammatory effects in a collagen-induced arthritis (CIA) mouse model.
We found that cartilage destruction and pannus formation were alleviated by treatment with XFHM.
The abnormal differentiation of Th1 and Th17 cells was downregulated significantly by XFHM, and Th2 and Treg cells were upregulated.
Moreover, the expression levels of specific cytokines and transcription factors related to Th1 cells (interferon γ [IFNγ], T-bet) and Th17 cells (interleukin- [IL-] 17) and the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (RORγ) were downregulated.
Serum IL-4 and GATA-3, which contribute to Th2 cells differentiation, increased significantly after XFHM administration.
These results indicate that XFHM can restore the balance of T lymphocytes and reestablish the immunological tolerance to inhibit autoinflammatory disorder of RA.
Taken together, XFHM can be used as a complementary or alternative traditional medicine to treat RA.
American Psychological Association (APA)
Nie, Bo& Li, Xue& Wei, Yi& Chen, Meng& Zhou, Jingwei& Li-Xia, Lou…[et al.]. 2016. Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1104279
Modern Language Association (MLA)
Nie, Bo…[et al.]. Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1104279
American Medical Association (AMA)
Nie, Bo& Li, Xue& Wei, Yi& Chen, Meng& Zhou, Jingwei& Li-Xia, Lou…[et al.]. Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1104279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104279