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Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain
Joint Authors
Cai, Lu
Wang, Chao
Huo, Xiao-kui
Dong, Pei-pei
Zhang, Bao-jing
Zhang, Hou-Li
Huang, Shan-shan
Zhang, Bo
Yu, Sheng-ming
Zhong, Ming
Ma, Xiao-Chi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Phyllodium pulchellum (P.
pulchellum) is a folk medicine with a significant number of bioactivities.
The aim of this study was to investigate the effects displayed by alkaloids fractions, isolated from the roots of P.
pulchellum, on neurotransmitters monoamine levels and on monoamine oxidase (MAO) activity.
Six alkaloids, which had indolealkylamine or β-carboline skeleton, were obtained by chromatographic technologies and identified by spectroscopic methods such as NMR and MS.
After treatment with alkaloids of P.
pulchellum, the reduction of DA levels (54.55%) and 5-HT levels (35.01%) in rat brain was observed by HPLC-FLD.
The effect of alkaloids on the monoamines metabolism was mainly related to MAO inhibition, characterized by IC50 values of 37.35 ± 6.41 and 126.53 ± 5.39 μg/mL for MAO-A and MAO-B, respectively.
The acute toxicity indicated that P.
pulchellum extract was nontoxic.
American Psychological Association (APA)
Cai, Lu& Wang, Chao& Huo, Xiao-kui& Dong, Pei-pei& Zhang, Bao-jing& Zhang, Hou-Li…[et al.]. 2016. Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104299
Modern Language Association (MLA)
Cai, Lu…[et al.]. Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104299
American Medical Association (AMA)
Cai, Lu& Wang, Chao& Huo, Xiao-kui& Dong, Pei-pei& Zhang, Bao-jing& Zhang, Hou-Li…[et al.]. Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104299