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Antihyperglycemic and Antiobesity Effects of JAL2 on dbdb Mice
Joint Authors
Lee, Seok-Geun
Jang, Hyeung-Jin
Kim, Ki-Suk
Kim, Kang-Hoon
Chung, Wonseok
Lee, In-Seung
Park, Jiyoung
Jeong, Hyeon-soo
Kim, Yumi
Na, Yun-Cheol
Ahn, Kwang Seok
Um, Jae-Young
Lee, Junhee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Lonicera japonica Thunb.
(LJT) and Rehmannia glutinosa Libosch.
(RGL) have been used traditionally as a herbal medicine in Korean medicine.
Using LC/Q-TOF was performed to profile the two herbal medicines and the mixture of LJR and RGL (JAL2, ratio 1 : 1).
We performed oral glucose tolerance test (OGTT) and plasma GLP-1 and insulin secretion by multiplex assays to investigate antidiabetic effects of LJT, RGL, and JAL2 in db/db mice, the mice model of type 2 diabetes mellitus (T2DM).
Also, the antiobesity-related factors such as plasma peptide YY (PYY), triglyceride, total cholesterol, HDL, LDL, and weight of liver, epididymal, and retroperitoneal fat tissue were investigated.
Through the multiplex assay, it was found that JAL2 treatment more efficiently attenuated high levels of blood glucose by stimulating GLP-1 secretion and reduced LDL concentration and weight of liver and retroperitoneal fat tissue compared to LJT or RGL treated separately.
These results suggest that the JAL2 has antidiabetes and antiobesity effects in T2DM mice model.
American Psychological Association (APA)
Lee, In-Seung& Kim, Ki-Suk& Kim, Kang-Hoon& Park, Jiyoung& Jeong, Hyeon-soo& Kim, Yumi…[et al.]. 2016. Antihyperglycemic and Antiobesity Effects of JAL2 on dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104300
Modern Language Association (MLA)
Lee, In-Seung…[et al.]. Antihyperglycemic and Antiobesity Effects of JAL2 on dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104300
American Medical Association (AMA)
Lee, In-Seung& Kim, Ki-Suk& Kim, Kang-Hoon& Park, Jiyoung& Jeong, Hyeon-soo& Kim, Yumi…[et al.]. Antihyperglycemic and Antiobesity Effects of JAL2 on dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104300