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Anti-Inflammatory Effects of Pomegranate Peel Extract in THP-1 Cells Exposed to Particulate Matter PM10
Joint Authors
Seok, Jin Kyung
Park, Soojin
Kwak, Jun Yup
Suh, Hwa-Jin
Kim, Young Mi
Boo, Yong Chool
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Epidemiological and experimental evidence support health risks associated with the exposure to airborne particulate matter with a diameter of <10 μM (PM10).
PM10 stimulates the production of reactive oxygen species (ROS) and inflammatory mediators.
Thus, we assumed that natural antioxidants might provide health benefits attenuating hazardous effects of PM10.
In the present study, we examined the effects of pomegranate peel extract (PPE) on THP-1 monocytic cells exposed to PM10.
PM10 induced cytotoxicity and the production of ROS.
It also increased the expression and secretion of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1), and cell adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).
PPE at 10–100 μg mL−1 attenuated the production of ROS and the expression of TNF-α, IL-1β, MCP-1, and ICAM-1, but not VCAM-1, in THP-1 cells stimulated by PM10 (100 μg mL−1).
PPE also attenuated the adhesion of PM10-stimulated THP-1 cells to EA.hy926 endothelial cells.
PPE constituents, punicalagin and ellagic acid, attenuated PM10-induced monocyte adhesion to endothelial cells, and punicalagin was less cytotoxic compared to ellagic acid.
The present study suggests that PPE and punicalagin may be useful in alleviating inflammatory reactions due to particulate matter.
American Psychological Association (APA)
Park, Soojin& Seok, Jin Kyung& Kwak, Jun Yup& Suh, Hwa-Jin& Kim, Young Mi& Boo, Yong Chool. 2016. Anti-Inflammatory Effects of Pomegranate Peel Extract in THP-1 Cells Exposed to Particulate Matter PM10. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104301
Modern Language Association (MLA)
Park, Soojin…[et al.]. Anti-Inflammatory Effects of Pomegranate Peel Extract in THP-1 Cells Exposed to Particulate Matter PM10. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104301
American Medical Association (AMA)
Park, Soojin& Seok, Jin Kyung& Kwak, Jun Yup& Suh, Hwa-Jin& Kim, Young Mi& Boo, Yong Chool. Anti-Inflammatory Effects of Pomegranate Peel Extract in THP-1 Cells Exposed to Particulate Matter PM10. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104301